Concerns about report suggesting glucosamine and chondroitin protect against cartilage loss
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منابع مشابه
Concerns about report suggesting glucosamine and chondroitin protect against cartilage loss.
We wish to raise several concerns about the validity and conclusions of the recent report from Martel-Pelletier and coauthors regarding potential effects of glucosamine and chondroitin (G +C) on cartilage loss over time. The report used data from the Osteoarthritis Initiative (OAI), a large observational study from which the authors attempted to draw inferences about the effects of these treatm...
متن کاملRisk assessment for glucosamine and chondroitin sulfate.
Glucosamine and chondroitin sulfate are two popular dietary ingredients present in dietary supplements intended to support joint health. A large body of human and animal research suggests that oral intakes of these ingredients, either alone or in combination, reduces joint pain and improves mobility in persons with osteoarthritis. The increased awareness and use of these ingredients in dietary ...
متن کاملGlucosamine Hydrochloride but Not Chondroitin Sulfate Prevents Cartilage Degradation and Inflammation Induced by Interleukin-1α in Bovine Cartilage Explants
OBJECTIVE Glucosamine hydrochloride (GH) and chondroitin sulfate (CS) are commonly used for the treatment of osteoarthritis (OA). The aim of this study was to assess their effects, alone and in combination, on preventing aggrecan degradation and inflammation in an in vitro model of OA. DESIGN To test the effects of GH and/or CS as a preventative treatment, cartilage explants were pretreated w...
متن کاملGlucosamine and Chondroitin Sulfate for Osteoarthritis
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 573 1. Glucosamine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 574 2. Chondroitin Sulfate . . . . . . . . . . . . . . . . ....
متن کاملClinical inquiries. Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis?
A systematic review of glucosamine sulfate use for osteoarthritis, based on early research (19561991), found that it has anti-inflammatory properties and rebuilds damaged cartilage. (1) These studies evaluated chondrocytes grown in culture and animal models. (1,2) Chondroitin sulfate also stimulates chondrocyte biosynthesis in both animal and in vitro studies. There is insufficient evidence to ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2015
ISSN: 0003-4967,1468-2060
DOI: 10.1136/annrheumdis-2015-207479